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Evidence-Based Dentistry

Resources to aid oral health providers in making clinical decisions


Randomized Controlled Trial  Involves at least one test/experimental treatment or inteverntion and one control treatment that can be a placebo treatment or no treatment

  • Concurrent enrollment of subjects and follow-up of the experiemental test- and control-treated groups,
  • Assignment of subjects to either the experimental treatment/intervention group or the control/placebo group through a random process, such as the use of a random-numbers table, and
  • Follow-up of both groups to determine the outcome.

Double-Blind Randomized Controlled Trials Double-blind trials contain the rigor and methodology of a randomized controlled trial, but in addition are conducted so that neither the patient nor the investigator knows whether the patient is receiving the experimental treatment or the control treatment.