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Evidence-Based Dentistry

Resources to aid oral health providers in making clinical decisions

Definition

Randomized Controlled Trial  Involves at least one test/experimental treatment or inteverntion and one control treatment that can be a placebo treatment or no treatment

  • Concurrent enrollment of subjects and follow-up of the experiemental test- and control-treated groups,
  • Assignment of subjects to either the experimental treatment/intervention group or the control/placebo group through a random process, such as the use of a random-numbers table, and
  • Follow-up of both groups to determine the outcome.

Double-Blind Randomized Controlled Trials Double-blind trials contain the rigor and methodology of a randomized controlled trial, but in addition are conducted so that neither the patient nor the investigator knows whether the patient is receiving the experimental treatment or the control treatment.

Definitions from: Forrest J, Miller SA, Overman PR, Newman MG. (2009). Evidence-Based Decision Making: A Translational Guide for Dental Professionals. Philadelphia:Wolters Kluwer.